Shock Wave Applicator
The functional prototype consists of a clinically usable shock wave applicator, capable of generating both single and tandem shock waves. It can be used for lithotripsy, as well as in the fields of oncology, orthopedics, and potentially rheumatology.
At its core is a shock wave generator based on the principle of multichannel discharge.
Photodynamic Therapy and Upconversion Nanoparticles in Cancer Biology
At our institute, we focus on the biological aspects of photodynamic therapy (PDT) for cancer treatment using upconversion nanoparticles (UCNPs), in collaboration with the Institute of Macromolecular Chemistry of the Czech Academy of Sciences. Photodynamic therapy represents a promising therapeutic approach based on light-induced activation of a photosensitizer, resulting in the generation of reactive oxygen species that selectively damage tumor cells.
Intelligent Systems for Targeted Cancer Immunotherapy
We develop innovative nanoparticle-based systems that enable the delivery of therapeutics directly to tumor tissue while activating the patient’s own immune system against the tumor. Our research focuses on the use of STING pathway agonists, silencing of the CD47 protein via RNA interference, and the induction of immunogenic cell death (ICD), which transforms tumor cells into a source of signals that stimulate anti-tumor immunity. Targeted delivery of these therapeutic agents using advanced drug delivery systems enhances treatment efficacy, reduces side effects, and opens new possibilities for combination immunotherapy in hard-to-treat cancers.